USMLE Step 2 CK Practice Test 2025 – Complete Exam Prep

Hypochromic refers to a decreased hemoglobin concentration within red blood cells. In the context of microcytic anemia, which is often characterized by smaller-than-normal red blood cells (microcytes), the term "hypochromic" indicates that these cells have less hemoglobin than normal cells. This results in the cells appearing paler when viewed under a microscope, as hemoglobin gives red blood cells their characteristic color.

Microcytic anemia is commonly associated with conditions such as iron deficiency anemia or thalassemia, where insufficient hemoglobin production leads to both microcytosis and hypochromia. Consequently, the recognition of hypochromic red blood cells is significant in diagnosing the underlying type of anemia and understanding the mechanisms affecting hemoglobin synthesis.

The other choices do not accurately define the term hypochromic in this context. For instance, a higher red blood cell count or the presence of reticulocytes is not necessarily related to the hemoglobin content within individual cells, and the shape of red blood cells pertains more to conditions like sickle cell disease rather than directly to whether they are hypochromic.