What medications are classic causes of drug-induced hepatitis?

What medications are classic causes of drug-induced hepatitis?

• A. Antibiotics, NSAIDs, and opioids
• B. TB medications, acetaminophen, and tetracycline
• C. Antidepressants, antihistamines, and corticosteroids
• D. Antiviral drugs, antipsychotics, and muscle relaxants

Answer: (B)

Drug-induced hepatitis can occur when certain medications cause liver inflammation due to toxic effects or an immune-mediated response. Among the listed categories, tuberculosis (TB) medications, particularly isoniazid and rifampin, are well-known culprits that can lead to drug-induced liver injury. Acetaminophen is notorious for its hepatotoxic potential, especially in overdose situations, and can cause severe liver damage. Tetracycline is another antibiotic that has been associated with liver injury, though it is less common. These medications are recognized for their potential to induce liver inflammation and affect liver function, leading to symptoms such as jaundice, elevated liver enzymes, and in severe cases, hepatic failure. Understanding the specific drugs that can cause this condition is crucial for clinicians, as it aids in the appropriate monitoring of liver function, early identification of adverse effects, and management of patients taking these medications.

Drug-induced hepatitis can occur when certain medications cause liver inflammation due to toxic effects or an immune-mediated response. Among the listed categories, tuberculosis (TB) medications, particularly isoniazid and rifampin, are well-known culprits that can lead to drug-induced liver injury. Acetaminophen is notorious for its hepatotoxic potential, especially in overdose situations, and can cause severe liver damage. Tetracycline is another antibiotic that has been associated with liver injury, though it is less common.

These medications are recognized for their potential to induce liver inflammation and affect liver function, leading to symptoms such as jaundice, elevated liver enzymes, and in severe cases, hepatic failure. Understanding the specific drugs that can cause this condition is crucial for clinicians, as it aids in the appropriate monitoring of liver function, early identification of adverse effects, and management of patients taking these medications.